Δ-9-Tetrahydrocannabinol, more commonly known as THC, is one of the most studied and most abundant cannabinoids in traditional cannabis varieties. It is best known for its psychoactive effect, meaning its ability to influence perception, mood and certain cognitive processes by interacting with the human endocannabinoid system.

A major cannabinoid with well-identified effects

THC works primarily by binding to CB1 receptors, which are highly concentrated in the brain. This interaction explains its typical effects: euphoria, relaxation, enhanced sensory perception and, depending on the context and individual sensitivity, altered time perception or reduced concentration.

Beyond its psychoactive properties, THC also shows anti-inflammatory potential and is the subject of clinical studies related to pain, appetite and nausea.

A historic turning point: isolating THC

THC was isolated for the first time in 1964 by Professor Raphael Mechoulam and his colleague Yechiel Gaoni at the Weizmann Institute in Rehovot, Israel. This discovery marked the beginning of modern cannabinoid research and opened the way to understanding the endocannabinoid system.

Natural THC, synthetic THC and applications

Although THC is naturally produced by the cannabis plant, a synthetic form also exists: dronabinol, commercialised under the name Marinol. It is used in certain strictly regulated medical contexts.

Today, THC remains a central topic in discussions surrounding medical use, regulation and the diversity of cannabis varieties worldwide.

Note: This article is for informational purposes only and is not a substitute for professional medical advice.